促甲状腺激素受体 (TSHR)是自身免疫性甲状腺疾病 (AITD)的主要靶抗原 ,在AITD的发病中起重要作用。近年来利用TSHR多肽或核酸直接免疫动物成功地建立起了与人类AITD接近的动物模型 ,产生了活性TSHR抗体 ,甲状腺肿伴淋巴细胞浸润及Graves眼征 ,进一步证明了TSHR在AITD的发病中的作用。目前认为TSHR基因突变仅为一种基因多态性表现 Thyroid-stimulating hormone receptor (TSHR) is a major target antigen of autoimmune thyroid disease (AITD) and plays an important role in the pathogenesis of AITD. In recent years, the use of TSHR polypeptide or nucleic acid directly immunized animals successfully established a human AITD animal model, resulting in active TSHR antibodies, thyroid lymphocytic infiltration and Graves eye syndrome, further evidence of TSHR in the pathogenesis of AITD effect. Currently, TSHR gene mutation is only one kind of gene polymorphism