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目的探讨苦参硷治疗慢性乙型肝炎的疗效。方法104例住院病人随机分为对照组和治疗组,每组各52例。对照组给甘利欣及常用护肝药物门冬钾镁、维生素等。治疗组在对照组治疗方法基础上加用苦参硷150 mg/d,加入糖水中滴注,两组疗程均为20 d。观察临床疗效、肝功能变化、乙肝标志物转换及副作用。结果治疗组与对照组,临床总有效率分别为82.69%(43/52)、65.38%(34/52),χ2=40.5,P<0.05,两组间差异有统计学意义;两组肝功能TSB分别为(24±14)μmol/L及39±18μmol/L,P<0.05,两组ALT分别为(63±28)U/L及(169±52)U/L,P<0.05;两组乙肝病毒HbsAg及/或HbeAg转阴情况分别为19.23%(10/52)、5.76%(3/52),χ2=4.30,P<0.05,两组差异有统计学意义。结论苦参硷确实能改善肝功能,抑制HBV复制,是治疗慢性乙肝的有效药物。
Objective To investigate the curative effect of matrine on chronic hepatitis B Methods 104 cases of inpatients were randomly divided into control group and treatment group, 52 cases in each group. The control group to Gan Lixin and commonly used liver protection drugs aspartate potassium magnesium, vitamins and so on. The treatment group in the control group based on the treatment with the addition of matrine 150 mg / d, add sugar instillation, the two courses of treatment were 20 d. To observe the clinical efficacy, changes in liver function, hepatitis B marker conversion and side effects. Results The total clinical effective rates were 82.69% (43/52), 65.38% (34/52), χ2 = 40.5, P <0.05 in the treatment group and the control group, respectively. There was significant difference between the two groups TSB were (24 ± 14) μmol / L and 39 ± 18 μmol / L respectively, P <0.05. The ALT was (63 ± 28) U / L and (169 ± 52) U / L, The HBsAg and / or HbeAg negative rates of group B were 19.23% (10/52), 5.76% (3/52) respectively, χ2 = 4.30, P <0.05. The difference between the two groups was statistically significant. Conclusion Matrine does improve liver function and inhibit HBV replication, which is an effective drug for the treatment of chronic hepatitis B.