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人乳头瘤病毒16型是导致宫颈癌发生的主要因素,其晚期蛋白L1在体内或体外可自组装形成VLP颗粒.作者构建了DNA疫苗载体pDRVI1.0-16L1,大提质粒后免疫BalB/C小鼠制备抗体,并对抗体进行了特异性鉴定,为HPV16L1预防性疫苗的进一步研究和应用奠定了基础.
Human papillomavirus type 16 is the main factor leading to cervical cancer, and its late protein L1 can self-assemble to form VLP particles in vitro or in vivo.We constructed the DNA vaccine vector pDRVI1.0-16L1 and immunized BalB / C Antibodies were prepared from mice and antibodies were specifically identified, which laid the foundation for further research and application of HPV16L1 preventive vaccine.