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目的:研究高选择性5α还原酶抑制剂(爱普列特)在较大剂量时对雄性SD大鼠生精功能的影响。方法:32只8周龄雄性SD大鼠随机分为喂服淀粉的空白对照(C)组、喂服爱普列特1 mg/d(EL)组、喂服爱普列特5mg/d(EH)组及喂服非那甾胺(F)组,每组8只。观察大鼠睾丸重量、血清睾酮和双氢睾酮水平、附睾精子计数和配对雌性大鼠妊娠阳性数等变化情况。结果:与C组相比,F组或EH组均有①抑制前列腺生长和减轻睾丸重量的作用(P<0.05);②降低血清双氢睾酮而升高睾酮水平;③抑制大鼠精子数量,同时影响雄性大鼠生育能力。结论:大剂量高选择性5α还原酶抑制剂(爱普列特)可抑制雄性SD大鼠前列腺、睾丸重量,抑制精子生成并降低雄性大鼠生育力。
AIM: To investigate the effect of high selective 5α-reductase inhibitor (Epristeride) on spermatogenic function in male SD rats at higher doses. Methods: Thirty-two male Sprague-Dawley rats, aged 8 weeks, were randomly divided into three groups: control group (C) fed with amylose, eriptyline 1 mg / d (EL) EH group and fed with finasteride (F) group, 8 rats in each group. The changes of testicular weight, serum testosterone and dihydrotestosterone levels, sperm count of epididymis and the number of positive pregnancy in matched female rats were observed. Results: Compared with group C, group F or group E inhibited the growth of prostate gland and decreased testicular weight (P <0.05); ② lowered serum DHT and increased testosterone; ③ inhibited sperm count, At the same time affect fertility in male rats. CONCLUSION: High-dose high selective 5α-reductase inhibitor (Epristeride) can inhibit prostate and testicular weight, inhibit sperm production and reduce fertility in male SD rats.