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慢性淋巴细胞白血病(慢淋)在欧美国家是较常见的一种白血病,约占白血病的25％。亚洲地区則较少,在我国约占白血病的2％。近年来,随着免疫生物学的进展以及对淋巴细胞的研究,对本病的认识日趋深入,本文仅就其近代进展情况综述如下。发病因素慢淋的病因迄今不明,但与以下一些因素有关: (一)性别及年龄:以男性多见,男女之比约2:1～3:1。90％的慢淋患者年龄在50岁以上(约2/3>60岁)。Zippin等报告839例慢淋患者,男性中位数年龄68.1岁;女性中位数年龄67.7岁。老年人免疫和吞噬功能低下,可能是易发慢淋的原因之一。 (二)遗传因素:1929年Dameshek等报告一对56岁的孪生兄弟,在60天内先后死于慢淋。25年后,他们的子女之一在53岁时也发了病。其他作者也报告与慢淋患者有血緣关系的亲属中有較高的发病率。
Chronic lymphocytic leukemia (CLL) is a common leukemia in Europe and the United States, accounting for about 25% of leukemia. Less in Asia, accounting for about 2% of leukemia in our country. In recent years, with the progress of immunobiology and lymphocyte research, the understanding of this disease is more and more in-depth, this article only summarizes its recent progress as follows. Causes of CLL The so far unknown, but with some of the following factors: (a) gender and age: more common in men, male to female ratio of about 2: 1 ~ 3: 1.90% of the patients with chronic lymphocytic age 50 years Above (about 2/3> 60 years old). Zippin et al reported 839 cases of chronic lymphocytic leukemia patients, with a median age of 68.1 years; the median age of females was 67.7 years. Immune and phagocytic dysfunction in the elderly may be one of the causes of CLL. (B) genetic factors: In 1929, Dameshek and other reports of a 56-year-old twin brother, died in 60 days, CLL. Twenty-five years later, one of their children became sick at the age of 53. Other authors also reported a higher incidence among kinship relatives of cLL patients.