猪油量与家兔动脉粥样硬化关系研究

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本实验采用大耳白家兔,观察猪油Ⅰ组(猪油占总能量42%)、猪油Ⅱ组(猪油占总能量的21%)和豆油组(豆油占总能量42%)与血脂水平、组织脂肪酸组成、主动脉组织形态和体重的关系。结果表明,实验后各组血脂水平不同,血清胆固醇浓度,猪油Ⅰ组、豆油组和猪油Ⅱ组分别升高到7.04、4.04和5.36mmol/L,甘油三酯分别为1.07、0.57和1.00mmol/L,TC/HDL-C比值分别为7.12、5.99和8.48。组织脂肪酸组成中,饱和脂肪酸含量除血清中猪油Ⅰ组最高和心肌中豆油组最低外,其余各组相似,多不饱和脂肪酸含量豆油组最高,猪油Ⅱ组次之,猪油Ⅰ组最低。主动脉大体观察,猪油Ⅰ组受检动物中均有斑块形成,其中条状斑块为4/5,大纤维斑块为1/5,豆油组点状斑块3/5,条状和大纤维斑块各占1/5,而猪油Ⅱ组点状和条状纤维斑块各占1/5,其余的末见异常变化。电镜观察结果与大体观察结果相似,猪油Ⅱ组最轻、豆油组次之,猪油Ⅰ组最重。 In this study, we used large white rabbits to observe the effects of lard Ⅰ (lard 42%), lard Ⅱ (lard 21%) and soybean oil (42% of the total energy of soybean oil) Blood lipid, tissue fatty acid composition, aortic morphology and body weight. The results showed that after the experiment, the levels of serum lipids in different groups were different. The levels of serum cholesterol, lard Ⅰ, soybean oil and lard Ⅱ were increased to 7.04, 4.04 and 5.36 mmol / L respectively, and the triglycerides were 1.07, 0.57 and 1.00 mmol / L and TC / HDL-C ratios were 7.12, 5.99 and 8.48, respectively. In the fatty acid composition, the content of saturated fatty acid was the highest in the group of lard oil and the lowest in the soybean oil group, the highest in the group of polyunsaturated fatty acids, the lowest in the group of lard oil Ⅱ and the lowest in the group of lard Ⅰ . Aortic general observation, lard group I animals were found in the plaque formation, of which 4/5 strip plaque, large fiber plaque 1/5, soybean oil spot plaque 3/5, strip And large fiber plaque accounted for 1/5, while the lard Ⅱ group of points and strip of fibrous plaque accounted for 1/5, the other end of abnormal changes. Electron microscopy observations were similar to the general observations. Lactobacillus group Ⅱ was the lightest, soybean oil group was the second, lard group Ⅰ was the heaviest.
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