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谷氨酸在脑缺血发作过程中通过α氨基3羟基5甲基4异恶唑丙酸盐(ＡＭＰＡ)受体起作用。在短暂性脑缺血的动物模型中应用一种新型、选择性的ＡＭＰＡ受体拮抗剂ＰＤ152247(ＰＮＱＸ)来研究其量效关系,并且对ＡＭＰＡ受体拮抗剂是否通过药物所致低温起保护作用作进一步探讨。通过
Glutamate acts through the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate (AMPA) receptor during cerebral ischemic attacks. A novel and selective AMPA receptor antagonist, PD152247 (PNQX), was used in animal models of transient ischemic attack to investigate its dose-response relationship and to investigate whether AMPA receptor antagonists protect against hypothermia induced by drugs For further discussion. by