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作者采用间歇给药方式,观察重组α-2a干扰素(IFN α-2a)治疗慢性丙型肝炎(CHC)的疗效,并与连续给药疗法的疗效作了比较。 接受观察的病人135例,年龄14～65岁,血清ALT水平持续升高(至少超过正常值上限的2倍)6个月以上,有慢性肝炎的组织学证据,血清抗-HCV阳性。将病人随机分成甲、乙两组,接受两种方案治疗:甲组连续用药,IFN α-2a 6MU,肌注,每周3次,连续用药9个月。乙组间歇用药,剂量用法同前,用药3个月后(第一疗程),停药6个月,再以相同的剂量和方法用药3个月(第二疗程)。
The authors used intermittent administration to observe the efficacy of IFN-α-2a in the treatment of chronic hepatitis C (CHC) and compared with the efficacy of continuous-dose therapy. 135 patients were observed, aged 14 to 65 years, serum ALT levels continued to rise (at least more than 2 times the upper limit of normal) more than 6 months, with histological evidence of chronic hepatitis, serum anti-HCV positive. The patients were randomly divided into A, B two groups, receiving two kinds of programs: A group of continuous medication, IFNα-2a 6MU, intramuscular injection, three times a week, continuous medication for 9 months. Group B intermittent medication, dose usage with the former, medication 3 months after (first course of treatment), withdrawal of 6 months, then the same dose and method of medication for 3 months (second course of treatment).