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哮喘气道重塑是气道炎症长期作用的结果,亦是哮喘不易根治的主要原因。研究发现TGF-β/smad蛋白信号通路在气道重塑的发生中起到至关重要的作用,Th17/CD4+CD25+调节性T细胞在哮喘发生中的作用也日益受到人们的关注,但其具体作用及其相关发生机制及联系还不是很明确,所以阐明smads蛋白家族生物学特性、smads蛋白家族对哮喘气道重塑的影响、Th17/CD4+CD25+调节性T细胞与气道重塑的关系、气道重塑中Smads蛋白家族对Th17/CD4+CD25+调节性T细胞的影响将为哮喘气道重塑发生机制的研究提供一个新的方向。
Airway remodeling of asthma is a long-term result of airway inflammation and is also a major cause of asthma not easily cured. The study found that TGF-|Â / smad protein signaling pathway play a crucial role in the development of airway remodeling. The role of Th17 / CD4 + CD25 + regulatory T cells in the development of asthma is also receiving increasing attention. However, The specific role and its related mechanism and connection is not yet clear, so elucidate the biological characteristics of smads protein family, smads protein family on the impact of airway remodeling, Th17 / CD4 + CD25 + regulatory T cells and airway remodeling The relationship between Smads protein family and Th17 / CD4 + CD25 + regulatory T cells during airway remodeling will provide a new direction for the study of the mechanism of airway remodeling in asthma.