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20世纪90年代中期,陆熙炎教授报道了亲核叔膦促进的联烯酸酯与缺电子烯烃和亚胺环加成反应.二十年来,作为高效构建功能化碳环及杂环化合物方法,叔膦促进的联烯酸酯环加成反应的发展和应用受到化学家的广泛关注.多样性的亲核叔膦和不同结构联烯酸酯的引入,可呈现多种类型的环加成反应.特别是手性叔膦的应用,高选择性地实现了对该类反应的不对称催化,为一些天然产物和药物模块的全合成开辟了新途径.此外,醛酮化合物也被运用到此类反应中,构建了多种有用的含氧杂环.本篇综述包括六部分:第一部分是引言,概括介绍陆氏反应;第二至五部分分别阐述了亲核叔膦促进联烯酸酯与缺电子烯烃、亚胺、醛酮以及特定亲核试剂的各种环加成反应;最后一部分是总结与展望.
In the mid-1990s, Professor Hee-heng reported the addition of nucleophilic tertiary phosphine-promoted alkenoates to electron-deficient alkenes and imine rings. For two decades, as a method for efficiently building functionalized carbocyclic and heterocyclic compounds, The development and application of phosphine-promoted bi-alkene cycloadditions have attracted the attention of chemists, and diversified nucleophilic tertiary phosphines and different structures of alkenolate esters can exhibit various types of cycloaddition reactions. Especially the application of chiral tertiary phosphine, the asymmetric catalysis of this type of reaction is highly selective, opening up new avenues for the total synthesis of some natural products and drug modules. In addition, aldehydes and ketones are also applied to this type In the reaction, a variety of useful oxygen-containing heterocycles were constructed.This review includes six parts: The first part is an introduction, which is a general introduction of the Lewis reaction. The second part to the fifth part respectively describe the effects of nucleophilic tertiary phosphine- Lack of electronic olefins, imines, aldehydes and ketones and specific nucleophiles various cycloaddition reactions; the last part is the summary and outlook.