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本文检测30例病理证实的成年慢性肝炎患者血清 LSP 阳性率及滴度均为 CAH>CPH(阳性率二组比 P>0.05,滴度 CAH 显著为高,t=2.6269,P<0.02)。LSP 滴度与肝脏病变严重程度密切相关,以桥形坏死(P<0.001)、碎屑状坏死(P<0.001)、界板破坏(P<0.01)三组最高。纤维组织增生组次之(P<0.05),其它病变均较低。同时发现前三组病变的抗—LSP 阳性率亦比其它病变高,分别为80.00%(P<0.01)、83.33%(P<0.001)和62.50%(P<0.05),若与血清 LSP 同时阳性更表明病变严重。SGPT 水平与肝脏病理变化无显著性相关。因此,似可认为检测血清 LSP 滴度或同时检测血清 LSP 和抗—LSP 可作为能较好间接反映病变活动性及病变严重程度的血清学指标。
The positive rate of serum LSP and the titer of CAH> CPH in serum of 30 patients with chronic hepatitis confirmed by pathology were significantly higher than those in control group (P <0.05, titers of CAH were significantly higher, t = 2.6269, P <0.02). LSP titers were closely related to the severity of hepatic lesions, and were highest in three groups: bridge necrosis (P <0.001), ficiform necrosis (P <0.001), and destruction of boundary plates (P <0.01). Fibrosis group followed (P <0.05), other lesions were lower. The positive rates of anti-LSP in the first three groups were also higher than those in the other groups (80.00%, 83.33%, P <0.001) and 62.50% (P <0.05) Even more serious lesions. There was no significant correlation between SGPT level and liver pathological changes. Therefore, it may seem that the detection of serum LSP titers or simultaneous detection of serum LSP and anti-LSP may serve as a good indirect indicator of lesion activity and the severity of the serological markers.