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目的:探讨巨噬细胞加帽蛋白(CapG)在肺癌临床病理特征、癌细胞转移和患者预后中的价值。方法:S-P免疫组化法检测63例有完整资料的肺癌患者癌组织标本及相应癌旁组织CapG蛋白表达,分析CapG蛋白与肺癌患者临床病理特征和转移预后的关系。结果:CapG蛋白肺癌细胞胞浆及胞核阳性表达为33.3%(21/63),并与肺癌组织学类型、肿瘤分化程度、肿瘤大小、临床分期、淋巴结转移及抽烟有关(P<0.05);Kaplan-Meier生存分析显示CapG蛋白阳性患者生存率较阴性患者为低(P<0.05),Cox风险比例模型显示淋巴结转移及CapG蛋白阳性可显著增加肺癌患者的死亡风险(P<0.05)。结论:CapG基因在肺癌发生发展中起重要作用,与肺癌转移及低生存率有关,可作为临床早期发现肺癌转移及预测预后的指标。
Objective: To investigate the value of CapG in the clinical and pathological features of lung cancer, the metastasis of cancer cells and the prognosis of patients. Methods: S-P immunohistochemical method was used to detect the expression of CapG protein in 63 cases of lung cancer with complete data and corresponding adjacent tissues. The relationship between CapG protein and the clinicopathological features and prognosis of lung cancer was analyzed. Results: The positive expression of CapG protein in cytoplasm and nucleus of lung cancer cells was 33.3% (21/63), which was correlated with histological type, tumor differentiation, tumor size, clinical stage, lymph node metastasis and smoking (P <0.05). Kaplan-Meier survival analysis showed that the survival rate of CapG positive patients was lower than that of negative patients (P <0.05). Cox risk proportional model showed that lymph node metastasis and CapG protein positive could significantly increase the risk of death in patients with lung cancer (P <0.05). Conclusion: CapG gene plays an important role in the development of lung cancer, which is related to the metastasis of lung cancer and low survival rate. It can be used as an indicator of lung cancer metastasis and prognosis in early stage.