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目的 :探讨白细胞介素 2 (IL - 2 )对鼻咽癌 (NPC)患者行放、化疗后免疫功能的影响。方法 :将 90例NPC患者随机平分为局部组 (IL - 2局部用药加放、化疗 )、全身组 (IL - 2静脉滴注加放、化疗 )和常规组 (化疗加放疗 )。另设 30例正常对照组。分别检测免疫治疗前后和放疗结束后患者的免疫功能 ,并与正常组比较。结果 :3组患者的细胞免疫功能治疗前均比对照组低下 (P <0 .0 1) ,体液免疫高亢 ;经 IL - 2治疗后 ,细胞免疫功能有所提高 ,但体液免疫变化不大。放、化疗后 ,全身组和局部组的免疫功能较治疗前变化不明显 ;常规组的细胞免疫功能明显低下 ,体液免疫功能仍无明显变化。结论 :1在放、化疗前 ,小剂量应用 IL - 2治疗对维护和提高 NPC患者的免疫功能有一定的作用 ,全身用药优于局部用药。 2 3种疗法对 NPC患者的体液免疫功能影响不大。
Objective: To investigate the effect of interleukin - 2 (IL - 2) on immune function in patients with nasopharyngeal carcinoma (NPC) after radiotherapy and chemotherapy. Methods: Ninety patients with NPC were randomly divided into two groups: local group (IL - 2 local drug plus radiotherapy and chemotherapy), systemic group (IL - 2 intravenous injection plus chemotherapy) and conventional chemotherapy plus radiotherapy. Another 30 cases of normal control group. The immune function of patients before and after immunotherapy and after the end of radiotherapy were tested and compared with the normal group. Results: The cellular immune function of the three groups was lower than that of the control group before treatment (P <0.01) and the humoral immunity was hyperactive. The cellular immunity was improved after IL - 2 treatment, but the humoral immunity did not change much. After radiotherapy and chemotherapy, the immune function of the systemic and local groups was not changed significantly compared with that before treatment. The cellular immunity of the conventional group was significantly lower and the humoral immune function remained unchanged. Conclusions: 1 Before the chemotherapy and chemotherapy, the low dose of IL - 2 treatment has a certain effect on the maintenance and improvement of immune function of NPC patients, and systemic administration is superior to topical application. 2 3 kinds of therapy on the humoral immune function in patients with little effect.