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作者最近发现给感染文氏疟原虫的小鼠注射四氧嘧啶后,高原虫血症消失。连续注射几次可治愈感染。这种抗疟作用可能是由四氧嘧啶与5-羟基巴比土酸之间的氧化还原循环所生成的反应型氧(可能是羟基)而引起的。体内试验:为确定游离氧根对疟原虫的影响,给感染鼠注射少量能直接分解产生游离氧根的有机过氧化氢物。在CBA/CaH小白鼠感染文氏疟原虫后,给予静脉注射0.5%叔-丁基过氧化氢(t-BHP)盐水200μl,隔2小时检查血片,发现有许多退行性变的红内
Recently, the authors found that allozymes were injected into mice infected with Plasmodium malaria, and parasitemia disappeared. Several times in a row can cure the infection. This anti-malarial effect may be caused by the reactive oxygen species, possibly hydroxyl, generated by the redox cycle between alloxan and 5-hydroxy-barbiturate. In Vivo Assay: In order to determine the effect of free oxygen on Plasmodium, a small amount of organic hydroperoxide that directly dissociates to produce free oxygen radicals is injected into infected mice. After CBA / CaH mice were infected with Plasmodium malaria, 200 μl of 0.5% tert-butyl hydroperoxide (t-BHP) saline was intravenously administered and the blood film was examined every 2 hours and found to have many degenerative red