近年来随着医学发展，临床上抗生素、激素和细胞毒药物更广泛使用，脏器移植、免疫缺陷疾病的发生等导致全身性深部真菌病的发病率急剧增加，且有较高的死亡率。因此为挽救病人的生命，需及时应用有效低毒的抗真菌药。迄今，两性霉素Ｂ仍是治疗深部真菌病疗效最确切的药物［１? In recent years, with the development of medicine, the clinical use of antibiotics, hormones and cytotoxic drugs has become more widespread, organ transplantation and immunodeficiency diseases have led to a sharp increase in the incidence of systemic deep mycosis with high mortality. Therefore, in order to save the patient’s life, timely and effective use of low toxicity antifungal drugs. To date, amphotericin B is still the most effective drug for the treatment of deep mycoses [1?