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星形胶质细胞瘤II级是最常见的低级别胶质瘤,手术是主要治疗手段。可能由于不同的基因亚型导致了II级星形胶质细胞瘤临床病程和预后差异较大。星形胶质细胞瘤分子病理学方面,报道较多的基因表达改变包括:细胞增殖与凋亡有关的分子Ki67、Fas/FasL;细胞周期调节通路TP53/P21/P27/P14;生长因子及其受体,包括PDGF配体和受体等;血管生成通路1:Cox-2,iNOS,VEGF;血管生成通路2:Angiopoietin-Tie2;其它与血管生成有关的基因如ING4;与肿瘤浸润有关的是基质金属蛋白酶MMP-2,MMP-9,Tenascin-C,Fn14等;另外还有DCC等。以上相关分子表达与星形胶质细胞瘤的发展和预后有关,但有肯定性结论的还不多,本文复习文献并分析这些相关分子表达与病人预后的关系。
Astroglioma grade II is the most common low-grade glioma, surgery is the main treatment. Class II astrocytomas may have different clinical course and prognosis due to different gene subtypes. Astroglioma molecular pathology, more gene expression changes reported include: cell proliferation and apoptosis-related molecules Ki67, Fas / FasL; cell cycle regulatory pathway TP53 / P21 / P27 / P14; growth factor and its Receptors, including PDGF ligands and receptors; angiogenesis pathway 1: Cox-2, iNOS, VEGF; angiogenesis pathway 2: Angiopoietin-Tie2; other angiogenesis-related genes such as ING4; associated with tumor invasion Matrix metalloproteinases MMP-2, MMP-9, Tenascin-C, Fn14, etc .; in addition to DCC and so on. The above related molecular expression and astrocytoma development and prognosis, but there are few conclusive conclusions, this article review the literature and analyze the relationship between the expression of these molecules and the prognosis of patients.