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目的:探讨血清MMP-7和MMP-10的检测在卵巢癌诊断中的意义。方法:选取59例卵巢癌患者,52例卵巢良性肿瘤患者和40例健康体检妇女(正常对照组)为研究对象。采用ELISA方法测定血清中MMP-7和MMP-10的水平。结果:恶性组血清MMP-7和MMP-10的水平明显高于良性组和对照组(P<0.01)。良性组血清MMP-10水平高于对照组(P<0.01)。血清MMP-7和MMP-10的ROC曲线下面积分别为0.723和0.826。血清MMP-7和MMP-10的联合诊断灵敏度为95.2%,特异度为94.8%。结论:血清MMP-7和MMP-10的检测可以用于卵巢癌的诊断,两者联合诊断可大大提高卵巢癌的检出率。
Objective: To investigate the significance of serum MMP-7 and MMP-10 in the diagnosis of ovarian cancer. Methods: 59 patients with ovarian cancer, 52 patients with benign ovarian tumors and 40 healthy women (normal control group) were selected as the research object. Serum levels of MMP-7 and MMP-10 were measured by ELISA. Results: Serum levels of MMP-7 and MMP-10 in malignant group were significantly higher than those in benign group and control group (P <0.01). The serum level of MMP-10 in benign group was higher than that in control group (P <0.01). The areas under the ROC curve of serum MMP-7 and MMP-10 were 0.723 and 0.826, respectively. The combined diagnostic sensitivity of serum MMP-7 and MMP-10 was 95.2% and the specificity was 94.8%. Conclusion: The detection of serum MMP-7 and MMP-10 can be used for the diagnosis of ovarian cancer. The combined diagnosis of both can greatly increase the detection rate of ovarian cancer.