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从长期、超生理剂量应用糖皮质激素对Runx2、Osterix、PPARγ2、C/EBPs、BMP-2、TGF等骨形成相关细胞因子的表达以及Wnt/β-catenin通路信号转导的影响,进而影响成骨细胞分化,探讨糖皮质激素诱发骨质疏松症的机制,并结合补肾中药对其调节作用,为中西医结合防治糖皮质激素性骨质疏松症提供理论依据,同时分析了成骨细胞分化与“肾主骨”的关系,从微观角度揭示了中医“肾藏精生髓主骨”理论的科学性和可靠性。
The effects of glucocorticoid on the expression of cytokines such as Runx2, Osterix, PPARγ2, C / EBPs, BMP-2, TGF and other Wnt / β-catenin signaling in long-term and supraphysiological doses and the influence of To investigate the mechanism of glucocorticoid-induced osteoporosis (osteoporosis) by combining with the regulating effect of kidney-invigorating traditional Chinese medicine on osteoporosis, to provide a theoretical basis for the prevention and treatment of glucocorticoid-induced osteoporosis by combining traditional Chinese and western medicine. At the same time, “Kidney main bone ” relationship, from the microscopic point of view of traditional Chinese medicine “kidney essence of marrow essence ” theory of science and reliability.