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作者将野型乙型流感病毒株B/山形/16/88中血凝素(HA)和神经氨酸酶(NA)基因与乙型流感病毒冷适应株B/安阿伯/1/66重组成重组疫苗病毒,在鸡胚中培养,收集尿囊液作为全病毒抗原;以无菌小牛肉浸汤作安慰剂,给血清抗体阴性的成年人注射。作者采用双盲法将25名血清血凝抑制(HI)效价≤1:4的接种者随意分组接受冷适应B/山
The authors compared wild type influenza B / Yamagata / 16/88 hemagglutinin (HA) and neuraminidase (NA) genes with influenza B cold adapted strain B / Ann Arbor / 1/66 The recombinant vaccinia virus was cultured in chicken embryos and the allantoic fluid was collected as the whole virus antigen. Sterile veal infusion was used as placebo, and the serum antibody-negative adults were injected. The authors used a double-blind approach to randomize 25 vaccinated persons with serum hemagglutination inhibition (HI) titer <1: 4 in cold adaptation B / Mountain