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目的评价孕妇接种甲型H1N1流行性感冒裂解疫苗(简称甲流疫苗)后的安全性。方法从自愿接种甲流疫苗的孕妇中按照孕早期和孕中后期分层,每一层随机抽取60名孕妇,同时设置对照组,观察孕妇接种甲流疫苗后出现的不良反应情况(Adverse Events Following Immunization,AEFI)以及比较接种组和对照组妊娠并发症、妊娠结局情况。结果孕妇接种甲流疫苗的不良反应发生率为6.67%,孕中后期和孕早期AEFI发生率差异无统计学意义(χ2校正=1.21,P>0.05);发生的AEFI全部为一般反应;接种组和对照组发生妊娠并发症的差异无统计学意义(Fisher确切概率P=0.16),发生不良结局的差异也无统计学意义(χ2=0.48,P>0.05)。结论甲流疫苗对孕妇接种是安全的,且于怀孕各期均可接种,为保护母亲及其婴儿免受甲流病毒侵袭,母亲在怀孕期间接种甲流疫苗是一种很好的选择。
Objective To evaluate the safety of pregnant women vaccinated with Influenza A H1N1 Influenza A (vaccine of influenza A). Methods Pregnant women who were vaccinated with H1N1 flu vaccine were divided into three groups according to the stages of pregnancy and mid-second trimester. Sixty pregnant women were randomly selected from each layer, and the control group was set up to observe the adverse reactions of pregnant women after receiving the flu vaccine (Adverse Events Following Immunization, AEFI) and comparison of pregnancy complications and pregnancy outcomes in vaccinated group and control group. Results The incidence of adverse reactions in pregnant women receiving A flu vaccine was 6.67%. There was no significant difference in the incidence of AEFI between the second trimester and the first trimester (χ2 = 1.21, P> 0.05) There were no significant differences in pregnancy complications between the control group and the control group (Fisher’s exact probability P = 0.16). There was also no significant difference in adverse outcomes (χ2 = 0.48, P> 0.05). Conclusion Influenza A vaccination is safe for pregnant women and can be vaccinated at all stages of pregnancy. In order to protect mothers and their infants against Influenus A, it is a good choice for mothers to receive Influenza A during pregnancy.