微小RNA在视网膜疾病中表达及功能的研究进展

来源 :国际眼科纵览 | 被引量 : 0次 | 上传用户：safafaffaf

【摘要】

：

微小RNA(miRNA)是一类内源性、非编码单链RNA,长度约为22个核苷酸,他们通过与靶mRNA的3’端非编码区结合来抑制基因的表达,参与调节组织器官的生长发育、分化、功能维持和凋

【作者】

：

李敏王方

【机构】

：

同济大学附属第十人民医院眼科

【出处】

：

国际眼科纵览

【发表日期】

：

2004年期

【关键词】

：

微小RNA 视网膜糖尿病视网膜病变老年性黄斑变性 microRNA retina diabetic retinopathy age-related macu

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微小RNA(miRNA)是一类内源性、非编码单链RNA,长度约为22个核苷酸,他们通过与靶mRNA的3’端非编码区结合来抑制基因的表达,参与调节组织器官的生长发育、分化、功能维持和凋亡等重要的生理过程.miRNA是近年来生命科学领域中的研究热点,越来越多的研究表明多种miRNA在眼部表达,其中超过250种miRNA在视网膜组织中表达并影响其生长、发育和功能.本文就近年来miRNA在视网膜疾病的表达及功能作一综述.

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微小RNA在视网膜疾病中表达及功能的研究进展

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