Survivin是近年来发现的一种肿瘤凋亡抑制蛋白。其在恶性肿瘤的表达具有高度特异性,高表达于几乎所有恶性肿瘤组织,而在正常成人组织中未见表达。Survivin在肿瘤发生、发展过程中起重要作用,已成为肿瘤治疗的新靶点。本文介绍了Survivin的分子生物学结构、分布、作用机制、功能及其在恶性肿瘤的诊断、治疗及预后中的关系。 Survivin is a tumor suppressor protein discovered in recent years. Its expression in malignant tumors is highly specific, highly expressed in almost all malignant tumor tissues, but not in normal adult tissues. Survivin plays an important role in tumorigenesis and development and has become a new target of tumor therapy. This article describes the molecular biology of Survivin structure, distribution, mechanism of action, function and its relationship in the diagnosis, treatment and prognosis of malignant tumors.