1969年,有人发现前列腺素(PG)内过氧化物(PGG_2,PGH_2)可被来自血管的一种微粒体酶转化成不稳定的物质,这种物质最初称之为PGX,有很强的血管扩张作用,并抑制血小板聚集。经化学鉴定认为是6-酮基-PGF_(1α)的前体物,后来根据PG先后发现的顺序把PGX改名为PGI_2(Prostacyclin,前列环素)。 1.PGI_2的来源及其性质目前认为PGI_2是一种循环激素,是花生四烯酸(AA)代谢的中间产物之一。AA通过磷脂酶A_2的作用从细胞膜磷脂中游离出来,通过环氧合酶的作用形成环内过氧化物(PGG_2,PGH_2),再由血管壁内皮细胞微粒 In 1969, it was found that prostaglandin (PG) peroxides (PGG_2, PGH_2) can be converted by a microsomal enzyme from blood vessels into an unstable substance, which was originally called PGX and has a strong blood vessel Dilate and inhibit platelet aggregation. It was chemically identified as a precursor of 6-keto-PGF_ (1α), and PGX was renamed PGI_2 (Prostacyclin, prostacyclin) according to the order in which PGs were discovered. The origin of PGI_2 and its nature PGI_2 is currently considered a circulating hormone, is one of the intermediates of arachidonic acid (AA) metabolism. AA is released from the phospholipids of the cell membrane by the action of phospholipase A_2, forming cyclic peroxides (PGG_2, PGH_2) by the action of cyclooxygenase and then by the endothelial cell particles