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饲予大鼠克山病病区粮引起血清淀粉酶与脂肋酶活性阵低，胰腺腺泡合成淀粉酶与脂肪酶的能力减弱，并伴有胰腺ＧＳＨ－Ｐｘ活力明显下降，ＬＰＯ合量升高，硒含量明显减少。在病区粮中补一定剂量晒或ＶＥ可明显提高血清淀粉酶与脂肪酶活性，增加肽腺腺泡淀粉酶与脂肪酶的合成，同时使ＧＳＨ－Ｐｘ活力升高，ＬＰＯ含量降低。此结果提示，克山病病区粮中的致病因素可引起胰腺外分泌功能的原发性损害，其机制可能与晒和ＶＥ缺乏有关。
Rats fed Keshan disease caused by serum amylase and lipase enzyme array low, the ability of pancreatic acinar synthesis of amylase and lipase weakened, accompanied by pancreatic GSH-Px significantly decreased vitality, increased LPO volume High, selenium content decreased significantly. In the ward to make up a certain dose of sun or VE dose of serum amylase and lipase activity can be significantly increased gland acinar cell enzyme and lipase synthesis, while GSH-Px increased vitality, LPO content decreased. The results suggest that the pathogenic factors in food of Keshan disease may cause primary damage of pancreatic exocrine function, which may be related to the lack of sun and VE.