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目的探讨羊膜联合角膜缘干细胞移植治疗眼表疾病的临床效果。方法选择有手术指征的各种眼表疾病病例300例,随机分为治疗组(A组),对照组(B组),每组150例(150)眼。A组行羊膜联合角膜缘干细胞移植术,B组行自体角膜缘上皮移植术,随访6～24月,观察眼表上皮修复、炎症反应、新生血管、视力等。结果角膜缘干细胞联合羊膜移植(A组)与自体角膜缘移植(B组)角膜上皮修复时间分别为3.1±0.2d和3.3±0.5d,应用u检验,P<0.01,认为两组存在统计学差异。A组3例(3眼)复发复发率为2%,B组11例复发复发率为7.33%,经X~2检验P<0.05,组间比较存在统计学差异。结论用羊膜联合角膜缘干细胞移植是一种有效的治疗眼表疾病的手段。
Objective To investigate the clinical effect of amniotic membrane transplantation combined with limbal stem cell transplantation in the treatment of ocular surface diseases. Methods 300 cases of ocular surface diseases with operation indication were selected and randomly divided into treatment group (A group) and control group (B group), with 150 cases (150 eyes) in each group. A group of amniotic membrane combined with limbal stem cell transplantation, group B autograft limbal epithelial transplantation, followed up for 6 to 24 months, observe the ocular surface epithelial repair, inflammation, neovascularization, visual acuity and so on. Results The corneal epithelial repair time of limbal stem cells combined with amniotic membrane transplantation (group A) and limbal autograft (group B) were 3.1 ± 0.2d and 3.3 ± 0.5d, respectively, using u test, P <0.01, difference. In group A, the recurrence rate was 2% in 3 cases (3 eyes), and the recurrence rate was 7.33% in group B (11 cases, P <0.05). There was significant difference between the two groups. Conclusion Amniotic limbal stem cell transplantation is an effective treatment of ocular surface diseases.