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目的探讨腹腔镜联合术前新辅助放化疗用于低位直肠癌保肛术的临床效果。方法将244例低位直肠癌患者随机分为观察组和对照组各122例。2组均予术前新辅助化疗。观察组采用腹腔镜,对照组采用开腹手术治疗,比较2组患者手术时间、术中出血量、保肛率及术后并发症发生率。结果观察组手术时间长于对照组,术中出血量少于对照组,保肛率高于对照组,术后并发症发生率低于对照组,差异均有统计学意义(P<0.05)。结论腹腔镜联合术前新辅助放化疗用于低位直肠癌保肛术具有显著的效果,可提高传统开腹手术保肛率,降低术后并发症的发生,疗效确切、并发症少、安全可靠,值得临床推广应用。
Objective To investigate the clinical effect of laparoscopy combined with neoadjuvant chemoradiation for preservation of low rectal cancer. Methods 244 cases of low rectal cancer patients were randomly divided into observation group and control group of 122 cases. Both groups were given neoadjuvant chemotherapy. The observation group was treated with laparoscopy and the control group with laparotomy. The operation time, intraoperative blood loss, anal sphincter preservation rate and postoperative complication rate were compared between the two groups. Results The operation time of the observation group was longer than that of the control group. The blood loss during the operation was less than that of the control group. The anal sphincter preservation rate was higher than that of the control group. The incidence of postoperative complications was lower than that of the control group (P <0.05). Conclusions Laparoscopic neoadjuvant chemoradiation and preoperative adjuvant chemoradiation is a safe and effective method for the treatment of low rectal cancer with anal sphincter preservation. It can enhance the anal sphincter preservation rate and reduce the incidence of postoperative complications. The curative effect is definite, the complication is less, the safety is more reliable ,Worthy of clinical application.