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以SnCl2作还原剂，酒石酸钠钾作中间络合剂，以纸层析法通过三种展开体系，研究了邻菲罗啉（Phed）的99mTc、188Re和稳定铼标记化学，并用离子交换法对99mTc－Phen的表观电荷进行了测定。结果显示，99mTc－Phen标记率可达95％以上；在pH1.0、沸水浴标记条件下，99mTc－Phen为两种或两种以上不同结构标记物的混合物；在pH5.0、室温标记条件下，99mTc－Phen有不同的纸层析行为和表观电荷性质，其稳定性虽较好；但比沸水浴产物差。99mTc－Phen标记物显正电性，但不同标记化合物的表观电荷及其随pH介质的变化有所不同。188Re和稳定铼标记要难于锝标记，在pH1.0、沸水浴条件下，即使大大提高SnCl2的用量，188Re最大标记率仍只有50％左右。
Using SnCl2 as reducing agent and sodium potassium tartrate as intermediate complexing agent, the 99mTc, 188Re and stable rhenium labeling chemistry of 1, 2-phenanthroline (Phed) were studied by paper chromatography through three unfolding systems. The ion exchange method The apparent charge of 99mTc-Phen was determined. The results showed that the 99mTc-Phen labeling rate was more than 95%. Under the conditions of pH1.0 and boiling water bath, 99mTc-Phen was a mixture of two or more different structural labels. At pH 5.0, , 99mTc-Phen has different paper chromatography behavior and apparent charge properties, although its stability is better; however, it is worse than the product of boiling water bath. 99mTc-Phen labels are positively charged, but the apparent charge of the different labeling compounds and their changes with the pH medium vary. 188Re and stable rhenium labeling is difficult to technetium labeling, pH1.0, boiling water bath conditions, even if greatly increased the amount of SnCl2, 188Re maximum labeling rate is still only about 50%.