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近10年来.大量的临床和实验研究表明高脂血症是进行性肾小球硬化的危险因素之一,但其机制尚不 十分清楚。最近我们观察了在微小氧化修饰低密度脂蛋白(MM-LDL)刺激下,体外培养大鼠系膜细胞分泌肿瘤坏死因子α(TNFα)的情况。从细胞水平探讨了脂质代谢紊乱在肾小球硬化中的作用。
The past 10 years, a large number of clinical and experimental studies have shown that hyperlipidemia is one of the risk factors for progressive glomerulosclerosis, but the mechanism is not yet clear. Recently we observed the secretion of tumor necrosis factor alpha (TNFα) by cultured rat mesangial cells stimulated by micro-oxidized low-density lipoprotein (MM-LDL). The role of lipid metabolism disorders in glomerulosclerosis was explored at the cellular level.