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用双抗体夹心ELISA法检测36例肾综合征出血热102份系列血清中IL－6含量，发现患者血清IL－6含量在6病日前及发热低血压期均高于正常；6病日达高峰，7病日开始下降；发热期明显升高，少尿期达峰值；IL－6含量在轻、中、重及危重型患者之间有明显差异；IL－6与尿蛋白在含量间明显正相关。提示IL－6含量变化与病程进展一致，是引起肾病综合征出血热病理损伤的重要因素之一；且与病情轻重密切相关，可一定程度判定患者预后和转归，反映肾损伤程度。
IL-6 in serum from 102 cases of hemorrhagic fever with renal syndrome was detected by double antibody sandwich ELISA, and the serum IL-6 level was higher than normal before the 6th day and the period of fever hypotension; , 7 day began to decline; fever increased significantly, the peak of oliguria; IL-6 levels were significantly different between mild, moderate, severe and critically ill patients; IL-6 and urine protein content was significantly positive Related. It is suggested that IL-6 content changes consistent with the course of disease progression and is one of the important factors that cause the pathological damage of hemorrhagic fever with nephrotic syndrome. It is closely related to the severity of illness, which can determine the prognosis and prognosis of patients to a certain extent and reflect the degree of renal injury.