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目的探讨对胃肠道肿瘤肝转移以盐酸槐定碱联合超液化碘油进行化疗栓塞(TACE)治疗的安全性与有效性。方法对29例胃肠道肿瘤肝转移患者以盐酸槐定碱及其它化疗药物联合超液化碘油进行化疗栓塞(TACE)治疗,评价其临床疗效及毒副反应。结果经盐酸槐定碱及其它化疗药物联合超液化碘油进行TACE治疗后,总有效率82.7%(24/29)。主要不良反应是肝功能损害,以I、II度为主,其次是发热、恶心呕吐及腹泻。结论以盐酸槐定碱及其它化疗药物联合超液化碘油进行化疗栓塞(TACE)治疗胃肠道肿瘤肝转移是一种安全有效的方法,其不良反应可耐受。
Objective To investigate the safety and efficacy of chemoembolization (TACE) in the treatment of hepatic metastasis of gastrointestinal tumors with sophoridine hydrochloride plus lipiodol. Methods Twenty-nine patients with hepatic metastasis of gastrointestinal tract were treated with chemotherapeutic embolism (TACE) with sophoridine hydrochloride and other chemotherapeutic agents combined with liquefied lipiodol. The clinical efficacy and adverse reactions were evaluated. The results of sophoridine hydrochloride and other chemotherapy drugs combined with liquefied iodized oil for TACE treatment, the total effective rate was 82.7% (24/29). The main adverse reaction was liver damage, with I, II degrees, followed by fever, nausea and vomiting and diarrhea. Conclusion Sophoridine hydrochloride and other chemotherapeutic agents combined with ultra-liquefied lipiodol for chemoembolization (TACE) in the treatment of hepatic metastases of gastrointestinal tumors is a safe and effective method, and its adverse reactions are tolerable.