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目的:探讨正常妊娠晚期凝血指标及血小板数值特异性与妊娠期糖尿病(GDM)的变化趋势。方法:对非孕生育期妇女100例和正常妊娠晚期妇女100例,妊娠晚期合并GDM 100例患者进行凝血指标及血小板数值监测。结果:与正常非孕生育期妇女相比,正常妊娠晚期凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、国际标准化比值(INR)显著降低(10.76s、26.62s、15.93s、0.85s),纤维蛋白原(Fg)和D-二聚体(DD)显著升高(4.10g/L、2.23g/L),血小板(PLT)2组样本均数相比差异无统计学意义;与正常妊娠晚期相比,GDM的PT、APTT、INR显著升高(11.27s、27.36s、0.89s);Fg、DD、PLT 2组样本数均差异无统计学意义。结论:正常妊娠晚期血凝呈高凝状态,妊娠期糖尿病呈病理性高凝,其凝血与继发性纤溶呈动态平衡,注意其凝血指标特殊性有助于及时诊断和(或)排除肺栓塞、弥散性血管内凝血。
Objective: To investigate the changes of coagulation index, platelet number specificity and gestational diabetes mellitus (GDM) in the normal third trimester of pregnancy. Methods: 100 cases of non-pregnant women during pregnancy and 100 cases of normal late pregnancy, GDM in the third trimester of pregnancy with coagulation parameters and platelet count monitoring. Results: Compared with normal non-pregnant women, PT, APTT, TT and INR significantly decreased in the third trimester of pregnancy (10.76s , 26.62s, 15.93s, 0.85s), fibrinogen (Fg) and D-dimer (4.10g / L, 2.23g / L) and PLT Compared with the normal pregnancy, PT, APTT, INR of GDM were significantly increased (11.27s, 27.36s, 0.89s); There was no statistical difference in the number of samples of Fg, DD, PLT between the two groups significance. Conclusion: In the third trimester of pregnancy, the hypercoagulability state is hypercoagulable and the hypercoagulability of gestational diabetes mellitus shows a dynamic balance between coagulation and secondary fibrinolysis. Pay attention to the specificity of coagulation index to diagnose and / or eliminate pulmonary Embolism, disseminated intravascular coagulation.