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目的:探讨新生儿母乳性黄疸阴阳属性转化的影响因素。方法:对68例确诊母乳性黄疸病例进行回顾性分析并追踪随访,第3至8周每周至少随访1次。记录患儿日龄、性别、胎龄、出生体质量、分娩方式、出生时窒息史、精神状态、皮肤颜色、每日喂奶次数、有无呕吐、大便情况、黄疸出现时间、经皮测胆红素值、口服退黄药物情况及黄疸消退时间等。化验血常规及肝功能指标。其中22例病程中曾由阳黄转化为阴黄。对此22例患儿(观察组)及其他患儿(对照组)临床资料进行统计。应用PEMS 3.1 For Windows统计软件进行分析。结果:观察组每日母乳喂养的次数(7.8±0.5 vs 8.2±0.7)、口服茵栀黄的天数(14.7±3.1 vs 12.6±2.9)及化验ALP、GGT值与对照组有不同,差异均有统计学意义(P<0.05)。黄疸消退时间较对照组延长(57.1±5.7 vs 52.9±6.2),差异有统计学意义(P<0.05)。结论:新生儿母乳性黄疸的阴阳属性可相互转化,其发生与多因素有关。不恰当服用寒凉药物、较高的血清ALP、GGT值可促进阳黄向阴黄转化,增加喂奶次数则通过促进黄疸消退而减少其转化。
Objective: To investigate the influencing factors of the conversion of yin and yang of neonatal milk-induced jaundice. Methods: 68 cases of breast milk jaundice confirmed by retrospective analysis and follow-up, Week 3 to Week 8 at least one visit. The age, sex, gestational age, birth weight, mode of delivery, history of asphyxia at birth, mental state, skin color, number of daily feeding, vomiting, stool, time of jaundice, Prime value, oral jaundice drugs and jaundice subsided time. Laboratory blood tests and liver function indicators. Of which 22 cases of Yang Huang was converted to yellow during the course of disease. The clinical data of 22 children (observation group) and other children (control group) were statistically analyzed. Application PEMS 3.1 For Windows statistical software for analysis. Results: The daily breastfeeding frequency (7.8 ± 0.5 vs 8.2 ± 0.7), the days of oral administration of Yinzhihuang (14.7 ± 3.1 vs 12.6 ± 2.9) and the ALP and GGT values in the observation group were significantly different from those in the control group Statistical significance (P <0.05). Jaundice dissipated longer than the control group (57.1 ± 5.7 vs 52.9 ± 6.2), the difference was statistically significant (P <0.05). Conclusion: The positive and negative attributes of breast milk jaundice in newborns can be transformed into each other, and its occurrence is related to many factors. Improper taking cold medicines, higher serum ALP, GGT value can promote the conversion of yang yellow to yinhuang, increase the frequency of feeding by jaundice to reduce and reduce its conversion.