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抑制素B(inhibin B,INHB)是由α及β(B型)亚单位构成的异源二聚体糖蛋白激素,属于转化生长因子β(transforming growth factor-β,TGFβ)超家族的一员。INHB在男性主要由睾丸支持细胞合成,在女性主要由卵巢的中、小窦卵泡颗粒细胞产生,其主要作用是通过负反馈机制抑制垂体促卵泡生成激素(follicular stimulation hormone,FSH)分泌,进而调节配子发生、发育,与雌雄两性生命活动密切相关。
Inhibin B (INHB) is a heterodimeric glycoprotein hormone composed of α and β (type B) subunits. It belongs to a member of transforming growth factor-β (TGFβ) superfamily . INHB is mainly produced by testicular sertoli cells in men and is mainly produced by granulosa cells of small and medium antral follicles in women. Its main function is to inhibit the secretion of follicular stimulation hormone (FSH) by the negative feedback mechanism and then regulate Gamete occurred, development, and male and female sex activities are closely related.