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目的:观察对侧网状巨细胞核(NGC)对脊髓伤害性信息传递的调制作用。方法:以浅麻醉和麻痹大鼠为对象,利用计算机平均技术,记录强电流刺激腓肠神经诱发的脊髓背表面电位(CDP),观察对侧网状巨细胞核微量注射 L-谷氨酸钠,使神经细胞体兴奋后对 CDP 的影响。对照组向对侧 NGC 内注射等量的人工脑脊液。CDP 变化用对照的百分数表示,统计学分析采用 t 检验,以 P<0.05为有显著性意义。结果:对侧 NGC 微量注射 L-谷氨酸钠后,CDP 中N_1波无显著性改变(P>0.05),P_1波及 N_3波分别减少到对照的70.68%±2.66%(P<0.01)和78.94%±7.91%(P<0.05),P_2波明显减小到对照的4.33%±3.1%(P<0.01),N_4波消失。结论:对侧 NGC 对细纤维诱发的 CDP 成分有抑制作用。
Objective: To observe the modulation of contralateral reticular giant cell nucleus (NGC) on nociceptive transmission of spinal cord. Methods: Sham anesthesia and paralyzed rats were used as the objects. The mean spinal cord surface potential (CDP) induced by high current stimulation was recorded by computer averaging technique. The contralateral reticular giant nuclei were injected with L-glutamate Effect of excitatory neuronal cell on CDP. The control group was injected with the same amount of artificial cerebrospinal fluid into the contralateral NGC. CDP changes expressed as a percentage of control, statistical analysis using t test, P <0.05 was considered significant. Results: There was no significant change of N 1 wave in CDP (P> 0.05), P_ (3) wave and N_3 wave decreased to 70.68% ± 2.66% (P <0.01) and 78.94 % ± 7.91% (P <0.05), P_2 wave was significantly reduced to 4.33% ± 3.1% of the control (P <0.01), N_4 wave disappeared. CONCLUSION: Contralateral NGC has an inhibitory effect on CDP induced by fine fibers.