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目的：探讨尿激酶型纤溶酶原激活物（uPA）、组织型纤溶酶原激活物（tPA）及纤溶酶原激活物抑制物1（PAI-1）表达与免疫不孕症机制的相关性。方法采用免疫组织化学及RT-PCR方法检测30例免疫不孕症患者（不孕组）及30名正常生育者（正常组）着床窗期子宫内膜uPA、tPA及PAI-1表达，并采用t检验进行统计。结果不孕组子宫内膜uPA （1.33±2.18）明显低于正常组（2.83±1.97），差异有统计学意义（P＜0.05）；不孕组子宫内膜PAI-1（2.68±1.72）明显高于正常组（1.24±1.90），差异有统计学意义（P＜0.01）；不孕组子宫内膜tPA与正常组差异无统计学意义（1.47±1.64、1.60±2.08，P＞0.05）。结论免疫不孕症患者着床窗期子宫内膜uPA/PAI-1与正常人具有明显差异，与免疫不孕症的发病机制具有密切关联。“,”Objective To explore the relevance between the uPA, tPA and PAI-1 of the endometrium and the mechanism of immune infertility.Methods Using immunohistochemistry, Western blot and RT-PCR methods test the expression of uPA, tPA and PAI-1 in the implantation window of endometrium fr om 30 cases immune infertility patients and 30 fertility (control group), and data using thet test.Results uPA of endometrium from immune infertility group (1.33±2.18) is signifi cantly lower than the control group (2.83±1.97), the difference is statistically significant (P<0.05); PAI-1 of endometrium from immune infertility group (2.68±1.72) is signifi cantly higher than control group (1.24±1.90), the difference is statistically signifi cant (P0.05).Conclusion uPA/PAI-1 of endometrium from the immune infertility patients and fertility has obvious difference, and it has a close correlation with the pathogenesis of immune infert ility.