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表皮生长因子受体(Epidermal growth factor receptor,EGFR)是一种跨膜蛋白受体,是ErbB家族成员之一,具有酪氨酸激酶活性。EGFR与相应的配体结合引起EGFR形成同源或异源二聚体启动胞内信号转导,激活下游多种信号转导途径,产生生物学效应,RAS/RAF/MEK/ERK通路与细胞增殖、分化和凋亡有关;PI3K/PDK1/AKT通路与细胞的迁移和粘附有关。EGFR能促进肺泡II型上皮细胞的成熟和肺表面活性物质的合成、分泌。EGFR对哺乳动物肺脏的作用呈现时空效应及剂量依赖效应,EGFR的下调表达则会引起肺脏发育不成熟;而EGFR过度表达促进肺肿瘤细胞的增殖、侵袭和转移。文章综述了EGFR及其调节信号通路的研究进展,以及EGFR与动物肺脏发育不成熟和肺癌之间的关系。
Epidermal growth factor receptor (EGFR), a transmembrane protein receptor, is a member of the ErbB family and has tyrosine kinase activity. The binding of EGFR to the corresponding ligands causes either homologous or heterodimers of EGFR to initiate intracellular signal transduction, activating various downstream signaling pathways, resulting in biological effects, RAS / RAF / MEK / ERK pathway and cell proliferation , Differentiation and apoptosis; PI3K / PDK1 / AKT pathway and cell migration and adhesion. EGFR can promote the alveolar type II epithelial cell maturation and pulmonary surfactant synthesis, secretion. The effect of EGFR on the lungs of mammals shows space-time effect and dose-dependent effect. The down-regulated expression of EGFR can cause immature lung development. EGFR overexpression promotes the proliferation, invasion and metastasis of lung cancer cells. This review summarizes the research progress of EGFR and its regulatory signaling pathways and the relationship between EGFR and lung development in lung and lung cancer.