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本文主要研究低浓度苯对果蝇生命周期的影响,建立相应的苯危害性工程评价模型,为进一步研究室内挥发性有机化合物(VOC)的叠加危害性提供研究方法基础。采用Oregon k黑腹果蝇作为受试生物,在动态染毒装置中进行0~600μg/m3低浓度水平的苯暴露实验。结果显示:8个实验组中,相同暴露时间下,雌性果蝇死亡数均高于雄性果蝇;随着苯的浓度升高,果蝇半数死亡时间(LT50)显著缩短,果蝇半数死亡时间与苯的浓度呈现良好的剂量-反应关系(相关性r=-0.988,显著性P<0.001);根据苯单独作用下的剂量-反应关系,建立了苯的危害性指数(HI)与浓度之间的Logistic回归模型(拟合度LRI=0.996)。
This paper mainly studies the effect of low concentration of benzene on the life cycle of Drosophila melanogaster, and establishes a corresponding engineering evaluation model of benzene hazard to provide the basis for further research on the hazards of indoor Volatile Organic Compound (VOC). Oregon k Drosophila melanogaster was used as the test organism, and benzene exposure experiments at a low concentration of 0-600 μg / m3 were performed in a dynamic exposure apparatus. The results showed that the mortality of female flies in the eight experimental groups was higher than that in male flies at the same exposure time. With the increase of benzene concentration, the half-life of the flies (LT50) was significantly shortened, and the half-lives of the flies And the concentration of benzene showed a good dose-response relationship (correlation r = -0.988, significant P <0.001). According to the dose-response relationship of benzene alone, the establishment of a benzene hazard index (HI) Between the logistic regression model (fitting degree LRI = 0.996).