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目的:探讨联合使用奥美拉唑、克拉霉素和阿莫西林治疗十二指肠溃疡的临床效果。方法:对2014年12月~2015年4月期间我院收治的64例十二指肠溃疡患者的临床资料进行回顾性研究。将这64例患者随机分为对照组和观察组,每组各有32例患者。我院对对照组患者使用奥美拉唑进行治疗,对观察组患者在使用奥美拉唑进行治疗(方法与对照组患者相同)的基础上,加用克拉霉素和阿莫西林进行治疗。治疗结束后,对比两组患者的治疗效果、幽门螺杆菌的清除率及其住院的时间。结果:观察组患者治疗的总有效率及幽门螺杆菌的清除率均明显高于对照组患者,其住院的时间明显短于对照组患者,二者相比差异具有显著性(P<0.05)。结论:对十二指肠溃疡患者联合使用奥美拉唑、克拉霉素和阿莫西林进行治疗,可有效地提高其治疗的效果及幽门螺杆菌的清除率,促进其病情的康复。此联合用药的方法值得在临床上推广使用。
Objective: To investigate the clinical effects of combining omeprazole, clarithromycin and amoxicillin in the treatment of duodenal ulcer. Methods: The clinical data of 64 patients with duodenal ulcer admitted in our hospital from December 2014 to April 2015 were retrospectively studied. The 64 patients were randomly divided into control group and observation group, each with 32 patients. Patients in the control group were treated with omeprazole in our hospital. Patients in the observation group were treated with clarithromycin and amoxicillin on the basis of treatment with omeprazole (the same method as the control group). After the treatment, the treatment effect, the clearance rate of Helicobacter pylori and the length of stay of the two groups were compared. Results: The total effective rate of treatment and the rate of Helicobacter pylori eradication in the observation group were significantly higher than those in the control group. The hospitalization time was significantly shorter than that in the control group. The difference was significant (P <0.05). Conclusion: The combination of omeprazole, clarithromycin and amoxicillin in patients with duodenal ulcer can effectively improve the therapeutic effect and the clearance rate of Helicobacter pylori, and promote the recovery of their condition. This combination therapy is worth promoting in clinic.