碘解磷定是抢救急性有机磷农药中毒的重要解毒药,大多数医药书上记载,可先用25％～50％葡萄糖液稀释静注,后用5％～10％葡萄糖液稀释静滴。据了解,很多医疗单位基本采用此法。近年提出,抢救急性有机磷农药中毒时,禁用葡萄糖液(尤其是高渗葡萄糖)稀释碘解磷定。过去药厂生产碘解磷定时,加入5％葡萄糖做稳定剂,现改用0.1％～0.2％焦亚硫酸钠。碘解磷定是胆碱酯酶复活剂,用葡萄糖液稀释,能使血浆活性胆碱酯酶浓度降低,从而使乙酰胆碱含量升高,易致中毒症状反复,甚至抢救失败。葡萄糖注入人体后,分解成丙酮酸,然后在线粒体内氧化脱羧,生成乙酰辅酶A,最后合 Iodine phosphate treatment is to rescue acute organophosphorus pesticide poisoning an important antidote, most of the medical records, you can use 25% ~ 50% glucose solution diluted intravenous infusion, diluted with 5% ~ 10% glucose solution intravenous infusion. It is understood that many medical units basically use this method. In recent years, the rescue of acute organophosphorus pesticide poisoning, the banned glucose solution (especially hypertonic glucose) diluted iodine phosphate set. In the past, the pharmaceutical factory produced iodine-decomposing phosphorus regularly, adding 5% glucose as stabilizing agent, now using 0.1% ~ 0.2% sodium metabisulfite. Iodine Phosphorus Defluoridation is a cholinesterase Resurrection agent, diluted with glucose solution, plasma concentrations of active cholinesterase can be reduced, so that the content of acetylcholine increased, easily lead to repeated symptoms of poisoning, and even failed rescue. Glucose into the human body, decomposed into pyruvate, and then oxidized and decarboxylated in the mitochondria to produce acetyl-CoA, and finally combined