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本文选择Sylysia(SiO2)为多孔载体材料,以非布索坦(febuxostat,FBT)为模型药物,制备非布索坦二氧化硅固体分散体并进行表征。首先我们建立了非布索坦的HPLC测定方法,对非布索坦固体分散体的DSC、PXRD、SEM和粒径进行表征,对非布索坦固体分散体的溶解度和溶出度进行测定。DSC和PXRD数据结果表明,非布索坦在固体分散体中以无定型存在。SEM和粒径结果表明,非布索坦固体分散体的粒径和Sylysia相近。溶解度和溶出度结果显示,非布索坦固体分散体的溶解度和溶出度相对于非布索坦而言显著提高。上述结果表明,所制备的非布索坦固体分散体可增加难溶性药物非布索坦的溶解度和溶出度。
In this paper, we chose Sylysia (SiO 2) as porous carrier material and febuxostat (FBT) as model drug to prepare and characterize the febuxostat solid dispersion. First of all, we established the HPLC method for the determination of febuxostat. The solid dispersion of febuxostat was characterized by DSC, PXRD, SEM and particle size. The dissolution and dissolution of the febuxostat solid dispersion were determined. DSC and PXRD data show that febuxostat is amorphous in solid dispersions. SEM and particle size results show that the particle size of the febuxostat solid dispersion is similar to Sylysia. Solubility and Dissolution The results show that the dissolution and dissolution of the febuxostat solid dispersion are significantly increased relative to febuxostat. The above results show that the solid dispersion of febuxostat prepared can increase the solubility and dissolution of the poorly soluble drug febuxostat.