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目的 研究急性脑梗死与活化血小板的关系。方法 采用单克隆抗体、流式细胞术测定 5 0例急性脑梗死患者入院次晨血浆 CD6 2 P、CD6 3,并与 2 0名正常人比较。结果 脑梗死患者血浆 CD6 2 P、CD6 3水平明显高于对照组 (均 P<0 .0 1)。大面积梗死组血浆 CD6 2 P、CD6 3水平明显高于中、小梗死组 (均 P<0 .0 1)。死亡组血浆 CD6 2 P、CD6 3水平高于存活组 (P<0 .0 1)。结论 急性脑梗死早期活化血小板明显升高 ,其升高水平与脑梗死范围成正相关。
Objective To study the relationship between acute cerebral infarction and activated platelets. Methods The plasma levels of CD62P and CD6 3 on the morning of admission in 50 patients with acute cerebral infarction were measured by monoclonal antibody and flow cytometry, and compared with 20 normal subjects. Results The levels of CD6 2 P and CD6 3 in patients with cerebral infarction were significantly higher than those in the control group (all P <0.01). The levels of CD6 2 P and CD6 3 in large infarct group were significantly higher than those in medium and small infarct group (all P <0.01). The levels of CD6 2 P and CD6 3 in the death group were higher than those in the survival group (P <0.01). Conclusion The activated platelet in the early stage of acute cerebral infarction is obviously increased, and the elevated level is positively related to the range of cerebral infarction.