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目的 : 探讨bcl- 2及P5 3蛋白在Bowen病及Bowen样鳞癌中的表达及其意义。方法 : 应用免疫组织化学技术对 11例Bowen病及 3例Bowen样鳞癌bcl- 2和 或P5 3蛋白的表达进行了检测。结果 :11例Bowen病中bcl- 2蛋白阳性 2例 (18% ) ,P5 3蛋白阳性 3例 (2 7% ) ;3例Bowen样鳞癌均见bcl- 2蛋白表达。Bowen病中bcl- 2与P5 3蛋白表达显著正相关 (r=0 .76 9,P <0 .0 5 )。结论 : Bowen病中bcl- 2蛋白表达与P5 3基因突变有关 ,并参与了Bowen病的进展及向Bowen样鳞癌的演变
Objective: To investigate the expression and significance of bcl-2 and P53 in Bowen’s disease and Bowen’s squamous cell carcinoma. Methods: Immunohistochemistry was used to detect the expression of bcl-2 and / or P53 protein in 11 cases of Bowen’s disease and 3 cases of Bowen’s squamous cell carcinoma. Results: In 11 cases of Bowen’s disease, bcl-2 protein was positive in 2 cases (18%) and P53 protein was positive in 3 cases (27%). The expression of bcl-2 protein in 3 Bowen-like squamous cell carcinomas was also observed. Bowen’s disease bcl-2 and P5 3 protein expression was significantly correlated (r = 0.769, P <0.05). CONCLUSIONS: The expression of bcl-2 protein in Bowen’s disease is related to the mutation of P53 gene and is involved in the progression of Bowen’s disease and its evolution to Bowen-like squamous cell carcinoma