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在非胰岛素依赖型糖尿病(NIDDM)患者中经常出现口服降糖药继发性失效,因而使用胰岛素治疗已成常规。然而,多种使用胰岛素替代治疗方法常有体重增加、低血糖等副作用。每日多次使用又给病人的工作和生活带来不便,不少病人不易坚持。为此,我们开展了睡前一次混合胰岛素的治疗,并取得了较为满意的疗效。本组共计20例病人,治疗时间为三个月。其中1例(5％)因出现皮疹等过敏反应而退出,其余19例(95％)完成试验治疗。该组病人睡前(晚十点左右)给予混合胰岛素0.26±0.07u/kg,经过三个月后空腹及餐后2小时血糖明显下降(P<0.05),糖化血红蛋白HbAlc也明显下降(P<0.05)。其中18例(90％)均达到治疗满意的要求。只有1例(5％)血糖HbAlc虽明显下降,但未达到满意标准。本试验中除1例出现过敏反应外,未出现体重明显增加和低血糖等副作用。
Oral hypoglycemic agents often fail secondary in patients with non-insulin-dependent diabetes mellitus (NIDDM), and insulin therapy has become routine. However, many alternatives to insulin replacement therapy often have weight gain, hypoglycemia and other side effects. Repeatedly used daily to the patient’s work and life inconvenience, many patients are not easy to adhere to. To this end, we conducted a mixed bedtime insulin treatment, and achieved more satisfactory results. A total of 20 patients in this group, the treatment time was three months. One patient (5%) withdrew due to an allergic reaction such as a rash and the remaining 19 (95%) completed the trial. The patients were given mixed insulin (0.26 ± 0.07u / kg at bedtime) before going to bed (around 10pm). After three months, their fasting and postprandial blood glucose dropped significantly (P <0.05) and HbAlc of glycated hemoglobin decreased significantly (P < 0.05). 18 of them (90%) met the requirements of satisfactory treatment. Only 1 (5%) HbA1c blood glucose decreased significantly, but did not meet the desired standard. In this test except 1 case of allergic reaction, no significant increase in body weight and hypoglycemia and other side effects.