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目的:观察夏枯草消瘤合剂联合化疗治疗中晚期非小细胞肺癌的临床疗效。方法:将60例中晚期非小细胞肺癌患者随机分为治疗组和对照组,每组30例。两组均予TP或GP方案化疗,治疗组同时加服夏枯草消瘤合剂。21 d为1个周期,2个周期后评价疗效。观察并比较两组的实体瘤疗效及中医证候积分、Karnofsky(KPS)评分、肿瘤标记物水平及毒副反应发生情况。结果:1治疗组和对照组的实体瘤疗效总有效率分别为33.3%和30.0%,组间比较差异无统计学意义(P>0.05)。2治疗后,两组患者的中医证候积分及KPS评分均显著降低(P<0.05),且治疗组患者的中医证候积分明显低于对照组(P<0.05),KPS评分高于对照组(P<0.05)。3治疗后,两组患者的癌胚抗原(CEA)、鳞癌相关抗原(SCC)水平较治疗前均显著降低(P<0.05),且治疗组患者的CEA、SCC水平低于对照组(P<0.05)。4治疗过程中,治疗组和对照组的毒副反应发生率分别为46.7%和73.3%,两组比较差异有统计学意义(P<0.05)。结论:夏枯草消瘤合剂联合化疗治疗中晚期非小细胞肺癌患者与单纯采用化疗治疗比较,能明显改善患者的临床症状,提高其生存质量,减轻化疗的毒副作用。
Objective: To observe the clinical efficacy of Prunella vulgaris combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Methods: Sixty patients with advanced non-small cell lung cancer were randomly divided into treatment group and control group, 30 cases in each group. The two groups were given TP or GP regimen chemotherapy, while the treatment group plus Prunella Xiaoyao mixture. 21 d for a period of 2 weeks after the evaluation of efficacy. The curative effect of solid tumor and TCM syndrome score, Karnofsky (KPS) score, tumor marker level and the incidence of toxic and side effects were observed and compared between the two groups. Results: The total effective rates of solid tumor in treatment group and control group were 33.3% and 30.0% respectively, there was no significant difference between the two groups (P> 0.05). After treatment, the TCM syndrome score and KPS score of both groups were significantly lower (P <0.05), and the scores of TCM syndromes in the treatment group were significantly lower than those in the control group (P <0.05), and the KPS scores were higher than those in the control group (P <0.05). 3, CEA and SCC in both groups were significantly lower than those before treatment (P <0.05), and the levels of CEA and SCC in the two groups were lower than those in the control group (P <0.05). 4 treatment, the treatment group and control group, the incidence of toxic reactions were 46.7% and 73.3%, the difference between the two groups was statistically significant (P <0.05). Conclusion: Prunella Xiaoyao Mixture combined with chemotherapy for patients with advanced non-small cell lung cancer compared with simple chemotherapy can significantly improve the clinical symptoms of patients, improve their quality of life and reduce the side effects of chemotherapy.