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ABC转运体(ATP Binding Cassettee Transporters)是一类分布较广、数目众多的跨膜转运体系。ABC乃是ATP-Binding-Cassettee3个字字首的缩写,中文可译为:与腺三磷结合的盒型转运体,迄今已发现有50余种,其中4/5分布于原核细胞,但在真核细胞中这类转运体系不断有所发现。典型的ABC转运体在结构上可分为4个微区(图1),其中两个为高度疏水的跨膜微区,每个跨膜微区由6个跨膜片段组成,但两者又不完全等同。高疏水跨膜微区
ABC transporters (ATP Binding Cassette Transporters) is a wide distribution, a large number of transmembrane transport system. ABC is the acronym for the prefix ATP-Binding-Cassettee3, which can be translated into: A box-type transporter binding to adenosine triphosphate. Up to now, there are more than 50 species, of which 4/5 are distributed in prokaryotic cells. However, Such transport systems in eukaryotes continue to be found. A typical ABC transporter is structurally divided into four domains (Figure 1), two of which are highly hydrophobic transmembrane domains and each transmembrane domain consists of six transmembrane segments, but both Not exactly the same. Highly hydrophobic transmembrane domain