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内皮素(ET)系产生于血管内皮细胞,含有21个氨基酸残基的多肽。ET是一类具有广泛生物作用的活性肽,可通过与受体结合后发挥其生物学效应,主要生理功能是缩血管和升压作用。对维持机体内环境稳定有着重要的影响。为探讨ET与肝病的关系,我们检测了住院的肝硬化及肝癌患者血浆ET水平变化,现报告如下。 材料与方法 一、研究对象:临床确诊为肝硬化失代偿期合并上消化道大出血30例,男29例,女1例,平均年龄42.5岁(29～70岁);临床确诊为原发性肝癌15例
Endothelin (ET) is produced in vascular endothelial cells, containing 21 amino acid residues of the polypeptide. ET is a class of active peptides with a broad range of biological effects that exert their biological effects by binding to receptors. The main physiologic functions are vasoconstriction and boosting. To maintain the stability of the environment within the body has an important impact. To explore the relationship between ET and liver disease, we examined the changes of plasma ET levels in hospitalized patients with cirrhosis and liver cancer, are as follows. MATERIALS AND METHODS 1. Subjects: Thirty patients with decompensated cirrhosis and upper gastrointestinal hemorrhage were enrolled in the study. There were 29 males and 1 females, with an average age of 42.5 years (29-70 years). The primary diagnosis was clinically diagnosed Liver cancer in 15 cases