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目的 探讨甲状腺乳头状腺癌 (PTC)组织中唾液酸化的路易斯 X(SialylLewis X ,SLeX)和 p16基因表达与肿瘤侵袭转移的关系。 方法 应用免疫组织化学技术检测 46例PTC组织中SLeX和 p16基因的表达。 结果 在PTC中 ,SLeX和 p16表达阳性率分别为 69 6%和 5 8 7% ,SLeX表达阳性率与PTC的侵袭转移呈正相关 (P <0 0 5 ) ;p16基因表达阳性率与PTC的侵袭转移呈负相关 (P <0 0 5 )。 结论 SLeX和 p16基因的表达与PTC侵袭转移密切相关 ,检测SLeX和p16基因的表达可作为判断PTC预后的参考指标
Objective To investigate the relationship between the expression of sialyl Lewis X (SLeX) and p16 gene and tumor invasion and metastasis in papillary thyroid carcinoma (PTC). Methods The expression of SLeX and p16 in 46 cases of PTC were detected by immunohistochemistry. Results The positive rates of SLeX and p16 in PTC were 69.6% and 58.7%, respectively. The positive rate of SLeX was positively correlated with the invasion and metastasis of PTC (P <0.05). The positive rates of p16 and PTC Metastasis was negatively correlated (P <0 05). Conclusion The expressions of SLeX and p16 genes are closely related to the invasion and metastasis of PTC. Detecting the expression of SLeX and p16 genes may be used as a reference index to judge the prognosis of PTC