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目的 :制备口腔溃疡的动物模型 ,研究复方珍珠散治疗口腔溃疡的作用并初步探讨其安全性。方法 :以醋酸致豚鼠口腔溃疡模型 ,观察复方珍珠散的治疗作用和皮肤用药的安全性。结果 :复方珍珠散能明显缩小由醋酸致豚鼠口腔溃疡的面积 ;无明显的皮肤过敏作用。结论 :复方珍珠散有明显的抗口腔溃疡作用 ,外用安全。
Objective : To prepare animal models of oral ulcers, to study the effect of Compound Zhenzhu Powder in the treatment of oral ulcers and to discuss its safety. METHODS: The guinea pig oral ulcer model induced by acetic acid was used to observe the therapeutic effect of compound Zhufangsan and the safety of skin medication. Results : The Compound Pearl Powder can significantly reduce the area of oral ulcers caused by acetic acid in guinea pigs; there is no obvious skin allergy. Conclusion : Compound pearl powder has obvious anti-oral ulcer effect and is safe for external use.