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目的探讨血管紧张素Ⅰ转换酶（ ACE）基因多态性与老年人 2型糖尿病（ T2DM）及糖尿病肾病（ DN）易感性之间的关系。方法应用 PCR三条引物法对 172例正常老年人（年龄≥ 60岁）， 140例 2型糖尿病（ T2DM）患者（其中 62例合并 DN）的 ACE基因多态性进行分析、比较。结果健康对照组与糖尿病组 ACE基因型、等位基因频率无显著差异（ P >0.05）。在 T2DM组中， DD基因型在合并 DN患者中显著增高（ P< 0.05）。结论 ACE基因多态性与糖尿病易感性无关，但与并发症 DN的发病密切相关。
Objective To investigate the relationship between the polymorphism of angiotensin Ⅰ converting enzyme (ACE) gene and the susceptibility to type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) in the elderly. Methods The polymorphism of ACE gene in 172 normal elderly (≥ 60 years old) and 140 T2DM patients (including 62 with DN) was analyzed by PCR with three primer pairs. Results There was no significant difference in ACE genotype and allele frequency between healthy control group and diabetic group (P> 0.05). In T2DM group, DD genotype was significantly higher in patients with DN (P <0.05). Conclusion ACE gene polymorphism has nothing to do with the susceptibility to diabetes, but closely related with the incidence of complications DN.