【摘 要】
：
IntroductionPaclitaxel (as Taxol) is a kind of diterpenoid natural product[1] extracted from Chinese yew. It has been reported to have high anti-tumor effects,
【机 构】
：
College of Pharmaceutical,Institute of Frontier Medical Science,Center of Drug Discovery
【基金项目】
：
the Scientific and Technological Development Program Foundation of Jilin Province
论文部分内容阅读
IntroductionPaclitaxel (as Taxol) is a kind of diterpenoid natural product[1] extracted from Chinese yew. It has been reported to have high anti-tumor effects, such as the activity against oophorama, mammary cancer, encephaloma, cervical carcinoma, and non- small-cell lung carcinoma[2-5]. One of the major problems of paclitaxel applied to therapy is its extremely low solubility in water[6]. In addition, paclitaxel is administered as a slow infusion in a vehicle consisting of Cremophor EL (polyoxyethylated castor oil ). However, Cremophor has been observed to cause severe, occasionally fatal hypersensitivity reactions in animals and humans[7].Therefore, paclitaxel therapy includes a prophylactic regimen of antihistamines and corticosteroids[8] , along with a prolonged infusion time to reduce the severity and incidence of hypersensitivity reactions. Because of the reasons mentioned above, currently its preparation needs to be improved further[9].
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